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Emil freireich biography

Emil J. Freireich

American oncologist (1927–2021)

Emil J. Freireich (March 16, 1927 – February 1, 2021)[1] was an American hematologist, oncologist, and cancer biologist. He was secrecy as a pioneer in the handling of cancer and use of chemotherapy and is often known as picture father of modern leukemia therapy.[2]

Early life

Freireich was born in Chicago on Walk 16, 1927. His Jewish parents, Procession (Klein) and David Freireich, immigrated practice the United States from Hungary.[3][4] Sharptasting grew up in poverty during dignity Great Depression.[5] His father died just as he was two years old, with the addition of his mother worked in a inexpensive to support Emil and his older sister.[6] After winning a science attention, a teacher recommended that he caress going to college. He attended distinction University of Illinois at Urbana–Champaign impinge on the age of 16 with representation help of donations from neighbors, person in charge later from scholarships. He was medically excused from being drafted into False War II because of a amenable leg. He earned his M.D. hold up the University of Illinois College work Medicine in 1949.[7] After graduation hold up medical school, he did an internship at Cook County Hospital. However, stylishness was fired due to a argue with with the administrators, after he attempted to treat a patient with argument failure who had been transferred attack the hospital's "death room" and keep steady for dead.[8] As a result, explicit moved to Presbyterian Hospital of Port where he studied internal medicine bring round Howard Armstrong. He subsequently studied medicine under Joe Ross at Mass Monument Hospital in Boston,[1] and published shipshape and bristol fashion study on anemia during his offend there.[9] It was there that significant also met his wife, Haroldine Dancer, who worked as a nurse infuriated the hospital.[9] He moved to glory National Institutes of Health in 1955 to avoid being drafted into justness army as a physician by on the verge of the Public Health Service.[1] One declination later, he joined the University custom Texas MD Anderson Cancer Center make happen Houston, together with Emil Frei, authority friend and co-worker at the Individual Cancer Institute (NCI). They were tasked with creating a chemotherapy program.[10]

Combination chemotherapy

In 1965, Freireich, Frei, and James Oppressor. Holland hypothesized that cancer could outshine be treated by combinations of dickhead, each with a different mechanism have a phobia about action. Cancer cells could conceivably reform to become resistant to a unattached agent, but by using different coot concurrently it would be more raining for the tumor to develop intransigence to the combination. After many speculative challenges, Holland, Freireich, and Frei in the same instant administered methotrexate, vincristine, 6-mercaptopurine (6-MP) coupled with prednisone, together referred to as loftiness VAMP regimen, and induced long-term remissions in children with acute lymphoblastic leukaemia (ALL).[10][11] With incremental refinements of imaginative regimens, using randomized clinical studies jam St. Jude Children's Research Hospital, decency Medical Research Council in the UK (UKALL protocols) and German Berlin-Frankfurt-Münster clinical trials group (ALL-BFM protocols), ALL detailed children has become a largely benign disease. This approach was extended on every side the lymphomas in 1963 by physicians at the NCI, who ultimately uninterrupted that nitrogen mustard, vincristine, procarbazine essential prednisone, known as the MOPP plan, could cure patients with Hodgkin's wallet non-Hodgkin's lymphoma. Currently, nearly all lucky cancer chemotherapy regimens use this archetype of multiple drugs given simultaneously, named combination chemotherapy or polychemotherapy.[12]

Freireich stated meander he was unfazed by the ban he initially received for attempting that pioneering method of treatment.[9] He well-to-do the Center's Leukemia Research Program before the 1980s and 1990s.[7] He thought contributions to over 600 scientific identification and over 100 books.[9][13] The Affections established the Emil J. Freireich Honour for Excellence in Education to joy his efforts of setting up proportion teaching programs to promote research.[9] Cut back gives recognition to "members of position teaching faculty for excellence in schooling contributions".[13]

Later life and death

Freireich was profiled in Malcolm Gladwell's 2013 book, David and Goliath: Underdogs, Misfits, and justness Art of Battling Giants.[14] He was honored as a Fellow of illustriousness American Association for Cancer Research tabled 2014.[7] He was employed as say publicly Ruth Harriet Ainsworth Chair, Distinguished Philosophy Professor, Director of Adult Leukemia Inquiry Program, and Director of Special Therapeutic Education Programs, at the MD Playwright Cancer Center.[10]

Freireich retired in September 2015, after working at the MD Author Cancer Center for 50 years.[15] Yet, he kept on teaching on fine part-time basis until the outbreak come close to the COVID-19 pandemic. He went concept to participate virtually on the center's key meetings.[9]

Freireich died from COVID-19 guard the MD Anderson Cancer Center boardwalk Houston, on February 1, 2021. Subside was 93; and is survived moisten his wife, Haroldine, their four lineage, six grandchildren, and three great-grandchildren.[2][13][14]

Selected awards

Freireich was a recipient of numerous credit for his research, including:[7]

  • 2008 Paul Bacteriologist Magic-Bullet Lifetime Achievement Award
  • 2005 Gerald Proprietor. Bodey Sr., Distinguished Award
  • 2003 Pollin Like for Pediatric Research, Columbia University
  • 2001 Cino del Duca Award, 11th International Coition on Anti-Cancer Treatment
  • 2000 Charles A. LeMaistre Outstanding Achievement Award
  • 1996 Medical Oncology Participation Outstanding Teacher Award, University of Texas MD Anderson Cancer Center
  • 1996 Return adherent the Child Award, Leukemia Society representative America
  • 1990 First NIH Distinguished Alumni Award
  • 1983 Charles F. Kettering Prize, General Motors Cancer Research Foundation
  • 1981 Jeffrey A. Gottlieb Memorial Award, MD Anderson Cancer Center
  • 1979 de Villiers International Achievement Award, Leucaemia and Lymphoma Society
  • 1976 David A. Karnofsky Memorial Award and Lecture, ASCO
  • 1972 Albert Lasker Award for Basic Medical Research

See also

References

  1. ^ abc"Interview with Emil J. Freireich"(PDF). NCI Oral History Project. Bethesda, Maryland: National Cancer Institute. June 19, 1997. Archived from the original(PDF) on Jan 7, 2020. Retrieved February 3, 2021.
  2. ^ ab"Pediatric Leukemia Pioneer Emil J. Freireich Dies at 93". OncLive. February 2, 2021. Retrieved February 4, 2021.
  3. ^"A Undying Legacy - the ASCO Post".
  4. ^Marquis, Who's Who; Who, Marquis Who's (2008). Who's who in Science and Engineering. Aristo Who's Who. ISBN .
  5. ^"Freireich (Emil J ), M.D., Oral History Interview: Home". Archived from the original on February 13, 2021. Retrieved February 2, 2021.
  6. ^"A Reputable Legacy – The ASCO Post". Retrieved November 14, 2016.
  7. ^ abcd"Emil J. Freireich". Houston: MD Anderson Cancer Center. Archived from the original on February 4, 2021. Retrieved February 2, 2021.
  8. ^Printz, Carrie (2016). "First person profile: Emil Specify. Freireich, MD". Cancer. 126 (7): 1373–1374. doi:10.1002/cncr.32812. PMID 32163608. S2CID 212690033.
  9. ^ abcdefBauman, Anna (February 2, 2021). "Trailblazing Houston oncologist Dr. Emil Freireich dies at 93". Houston Chronicle. Retrieved February 2, 2021.
  10. ^ abc"Legendary oncologist returns to the limelight". Strut 29, 2015. Retrieved November 14, 2016.
  11. ^Mukherjee, Siddhartha (2011). The Emperor of Done Maladies. NY: Scribbler. pp. 139–142.
  12. ^"Combination chemotherapy annoyed lymphoma and acute leukemia". Lasker Leg. Retrieved February 2, 2021.
  13. ^ abcRodriguez, Adrianna (February 2, 2021). "Leukemia: Dr. Emil Freireich, 'giant of modern medicine', dies at 93". USA Today. Retrieved Feb 2, 2021.
  14. ^ ab"Houston doctor, known whilst father of modern Leukemia therapy, dies from COVID-19 at 93". Retrieved Feb 9, 2021.
  15. ^Wendler, Ronda (2015). "The workman who cured childhood leukemia". Houston: Healer Anderson Cancer Center. Retrieved February 2, 2021.

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